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Peripheral chemerin administration modulates hypothalamic control of feeding
Luigi Brunetti1, Giustino Orlando1, Claudio Ferrante1
1Department of Pharmacy, "G. d'Annunzio" University, via dei Vestini 31, 66013 Chieti, Italy.
Peptides
|November 26, 2013
Summary
Chemerin administration in rats reduced food intake and body weight. This effect was linked to increased hypothalamic serotonin synthesis and release, suggesting a role in appetite regulation.
Area of Science:
- Endocrinology
- Neuroscience
- Metabolic Research
Background:
- Chemerin is an adipokine implicated in adipogenesis, energy metabolism, and inflammation.
- Understanding chemerin's role in feeding regulation is crucial for metabolic research.
Purpose of the Study:
- To investigate chemerin's effect on food intake and body weight in rats.
- To examine chemerin's influence on hypothalamic peptidergic and aminergic modulators involved in feeding regulation.
Main Methods:
- Adult male Wistar rats received daily intraperitoneal injections of vehicle or chemerin (8 or 16 μg/kg) for 17 days.
- Food intake and body weight were monitored.
- Hypothalamic gene expression (AgRP, NPY, orexin-A, CRH, POMC, CART) and monoamine concentrations (dopamine, norepinephrine, serotonin) were analyzed.
Main Results:
- Chemerin administration significantly decreased food intake and body weight in a dose-dependent manner.
- Chemerin treatment led to increased hypothalamic serotonin synthesis and release.
- Gene expression analysis suggested a limited role for chemerin as a peripheral appetite regulator.
Conclusions:
- Chemerin exerts appetite-suppressing effects in rats, mediated partly by enhanced hypothalamic serotonin activity.
- These findings highlight chemerin's potential involvement in central feeding regulation, distinct from its peripheral roles.
Keywords:
3,4-dihydroxyphenylacetic acid5-HIIA5-HT5-hydroxyindolacetic acidARCAgRPAgouti-related peptideCARTCRHChemerinDADOPACFeedingHVANENPYOrexin APOMCReal-time RT PCRSerotoninagouti-related peptidearcuate nucleuscocaine and amphetamine-regulated transcriptcorticotrophin releasing hormonedopaminehomovanillic acidl-dopalevodopaneuropeptide Ynorepinephrinepro-opiomelanocortinreal-time reverse transcription polymerase chain reactionserotoninMore Related Videos
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