Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Potentiation01:25

Long-term Potentiation

2.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
2.7K
Long-term Potentiation01:35

Long-term Potentiation

51.6K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
51.6K
Amnesia01:13

Amnesia

958
Amnesia is a condition marked by long-term memory loss, which impairs the ability to recall past events or create new memories.
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...
958
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

2.0K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
2.0K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.2K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.2K
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tungsten carbide-cobalt can function as a particle positive control for genotoxicity in vitro in specific cell lines.

Mutagenesis·2025
Same author

Harnessing the power of an advanced in vitro 3D liver model and error-corrected duplex sequencing for the detection of mutational signatures.

Mutagenesis·2025
Same author

Understanding the cellular uptake and genotoxic potential of industrial relevant nanomaterials utilizing electron microscopy and the ToxTracker assay in vitro.

Mutagenesis·2025
Same author

Red Algae Alters Expression of Inflammatory Pathways in an Osteoarthritis <i>In Vitro</i> Co-Culture.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

The dispersion method does not affect the in vitro genotoxicity of multi-walled carbon nanotubes despite inducing surface alterations.

NanoImpact·2024
Same author

Systemic Fluoroquinolone Use and Risk of Uveitis or Retinal Detachment.

JAMA ophthalmology·2024

Related Experiment Video

Updated: May 5, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

3.3K

Can temporal lobe epilepsy surgery ameliorate accelerated long-term forgetting?

Stephen J Evans1, Gemma Elliott1, Hazel Reynders2

  • 1Clinical Psychology Unit, Department of Psychology, The University of Sheffield, Sheffield S10 2TP, UK.

Neuropsychologia
|November 26, 2013
PubMed
Summary

Accelerated long-term forgetting (ALF) in temporal lobe epilepsy (TLE) may improve after surgery controlling seizures. However, results suggest seizure control isn't the only factor influencing memory retention.

Keywords:
Accelerated long-term forgettingEpilepsy surgeryMemorySeizuresTemporal lobe epilepsy

More Related Videos

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

13.7K
Using a Bipolar Electrode to Create a Temporal Lobe Epilepsy Mouse Model by Electrical Kindling of the Amygdala
09:49

Using a Bipolar Electrode to Create a Temporal Lobe Epilepsy Mouse Model by Electrical Kindling of the Amygdala

Published on: June 29, 2022

3.0K

Related Experiment Videos

Last Updated: May 5, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

3.3K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

13.7K
Using a Bipolar Electrode to Create a Temporal Lobe Epilepsy Mouse Model by Electrical Kindling of the Amygdala
09:49

Using a Bipolar Electrode to Create a Temporal Lobe Epilepsy Mouse Model by Electrical Kindling of the Amygdala

Published on: June 29, 2022

3.0K

Area of Science:

  • Neuropsychology
  • Epilepsy Research
  • Memory Consolidation

Background:

  • Accelerated long-term forgetting (ALF) is a memory deficit linked to temporal lobe epilepsy (TLE).
  • ALF involves intact short-term memory but rapid forgetting over longer periods (≥24h).
  • Seizure activity disrupting memory consolidation is a proposed cause of ALF in TLE.

Purpose of the Study:

  • To investigate if epilepsy surgery-induced seizure control improves ALF in TLE patients.
  • To compare memory retention in TLE patients and healthy controls before and after surgery.
  • To explore the relationship between seizure control, memory consolidation, and ALF.

Main Methods:

  • Compared seven TLE patients and 25 healthy controls matched demographically.
  • Administered parallel verbal and visual memory tests assessing free recall and recognition.
  • Assessed memory at pre-surgery and post-surgery time points, with delays of seconds, 30 minutes, and one week.

Main Results:

  • Pre-surgery, TLE patients showed significantly poorer retention over one week compared to controls.
  • Post-surgery, TLE patients demonstrated improved verbal and visual memory retention.
  • Individual patient analyses revealed heterogeneity in ALF and post-surgical memory improvement.

Conclusions:

  • Findings support the theory that uncontrolled seizures contribute to ALF in TLE.
  • Epilepsy surgery may enhance memory retention by stabilizing consolidation processes.
  • Other factors, potentially involving neocortical or medial temporal lobe integrity, also influence slow consolidation.