Related Experiment Video
Updated: May 5, 2026
04:59
Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
Published on: August 18, 2023
1.7K
Alternative carriers in dry powder inhaler formulations
Yahya Rahimpour1, Maryam Kouhsoltani2, Hamed Hamishehkar3
1Biotechnology Research Center and Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Discovery Today
|November 26, 2013
Summary
Choosing the right carrier powder is crucial for effective dry powder inhaler (DPI) drug delivery. This review explores alternatives to lactose, highlighting their pros and cons for improved pulmonary deposition.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery
- Materials Science
Background:
- Powder aerosolization efficiency for dry powder inhalers (DPIs) depends on carrier properties like particle size, shape, and surface.
- Achieving high and reproducible pulmonary deposition is a primary goal in inhalation therapy.
- Lactose is a common DPI carrier but has limitations with specific drugs and peptides.
Purpose of the Study:
- To critically review alternative carrier materials to lactose for DPI formulations.
- To analyze the merits, demerits, and applications of these alternative carriers.
- To provide insights for optimizing DPI formulation development.
Main Methods:
- Literature review of alternative carrier materials for DPIs.
- Critical analysis of carrier properties influencing aerosolization and pulmonary deposition.
- Comparative assessment of lactose versus alternative carriers.
Main Results:
- Several alternative carriers to lactose exist, each with unique advantages and disadvantages.
- Carrier properties significantly impact drug aerosolization and lung delivery performance.
- Optimizing carrier selection and processing is key to successful DPI formulation.
Conclusions:
- Alternative carriers offer solutions where lactose is unsuitable for DPI formulations.
- Careful selection and processing of carriers are essential for efficient pulmonary drug delivery.
- This review provides a guide for selecting appropriate DPI carriers beyond lactose.
Related Concept Videos
01:23Inhaled Medications
1.1K
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
1.1K
01:22Drug Delivery: Miscellaneous Routes
1.2K
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
1.2K
01:30Asthma-IV: Diagnostic and Management
3.4K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.4K
01:23Oral Drug Delivery Systems: Introduction
284
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
284
01:18Additional Routes of Drug Administration
5.3K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
5.3K
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
165
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
165