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Updated: May 5, 2026

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
Published on: July 17, 2020
Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity
Georgia Fousteri1, Stamatis-Nick C Liossis, Manuela Battaglia
1San Raffaele Scientific Institute, Diabetes Research Institute, Via Olgettina 58, Milan, Italy.
Abstract:
PTPN22 is a protein tyrosine phosphatase expressed by the majority of cells belonging to the innate and adaptive immune systems. Polymorphisms in PTPN22 are associated with several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and type 1 diabetes. This review discusses the role of PTPN22 in T and B cells, and its function in innate immune cells, such as monocytes, dendritic cells and NK cells. We focus particularly on the complexity that underlies the function of PTPN22 in the biological processes of the immune system; such complexity has led various research groups to produce rather conflicting data.
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