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Updated: May 5, 2026

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
Published on: November 22, 2014
A brief review of methods for terminal functionalization of DNA
Yuanchen Dong1, Dongsheng Liu1, Zhongqiang Yang1
1Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China.
Abstract:
The functionalized DNA has been widely developed and played a more and more important role in life science and material science during last decades. Therefore, methods to effectively endue DNA new functions by modifying DNA have been developed quickly. In this review, we will give an introduction in the methods for covalent terminal functionalization of DNA, including solid-phase functionalization and solution coupling functionalization, mainly on the technical aspect. The application of these functionalized DNA will be also introduced.
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