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Evaluation of renal involvement in children with Crimean-Congo hemorrhagic fever

Köksal Deveci1, Elif Bilge Uysal, Ali Kaya

  • 1Department of Clinical Biochemistry, School of Medicine, Cumhuriyet University.

Japanese Journal of Infectious Diseases
|November 26, 2013
PubMed

Insights

Children with Crimean-Congo hemorrhagic fever (CCHF) show kidney damage. Elevated urine neutrophil gelatinase-associated lipocalin (uNGAL) and protein levels indicate renal involvement, suggesting these markers can monitor kidney health in CCHF patients.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Nephrology

Background:

  • Crimean-Congo hemorrhagic fever (CCHF) is a severe viral illness.
  • Renal involvement is a potential complication of CCHF, particularly in pediatric cases.
  • Early detection of kidney damage is crucial for managing CCHF.

Purpose of the Study:

  • To assess renal involvement in children diagnosed with CCHF.
  • To investigate the utility of urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine protein as biomarkers for kidney damage in pediatric CCHF.
  • To compare clinical and laboratory findings between CCHF patients and healthy controls.

Main Methods:

  • A case-control study involving 44 children with CCHF and 30 healthy controls.
  • Measurement of urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine total protein levels in both groups.
  • Comparison of clinical and laboratory parameters, including proteinuria and uNGAL levels, between patient and control cohorts.

Main Results:

  • Children with CCHF exhibited significantly higher uNGAL levels compared to controls (P < 0.001).
  • Proteinuria was present in 59.1% of CCHF patients.
  • Elevated uNGAL levels were observed in proteinuric CCHF patients, with a positive correlation between uNGAL and urine protein (R = 0.614, P < 0.001).

Conclusions:

  • Pediatric CCHF cases demonstrate significant renal involvement.
  • Increased urine protein and elevated uNGAL levels are indicative of kidney damage in children with CCHF.
  • Monitoring uNGAL and urine total protein levels can aid in assessing and managing renal complications in pediatric CCHF.

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