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Updated: Aug 2, 2026
Screening Assay for Oxidative Stress in a Feline Astrocyte Cell Line, G355-5
Published on: July 13, 2011
Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients
Taysa Ribeiro Schalcher1, Jose Luiz Fernandes Vieira, Claudio Guedes Salgado
1Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Pará, BelémPA.
Introduction:
The immune response caused by Mycobacterium leprae is a risk factor for the development of oxidative stress (OS) in leprosy patients. This study aimed to assess OS in leprosy patients before the use of a multidrug therapy.
Methods:
We evaluated the nitric oxide (NO) concentration; antioxidant capacity; levels of malondialdehyde, methemoglobin and reduced glutathione; and the activity of catalase and superoxide dismutase (SOD) in leprosy patients.
Results:
We observed lower SOD activity in these leprosy patients; however, the NO levels and antioxidant capacity were increased.
Conclusions:
The infectious process in response to M. leprae could primarily be responsible for the OS observed in these patients.
