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Updated: May 5, 2026

Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty
10:46

Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty

Published on: September 17, 2014

14.8K

DMEK Complications

Mark S Gorovoy1

  • 1Fort Myers, FL.

Cornea
|November 26, 2013
PubMed
Abstract

Insights

Descemet membrane endothelial keratoplasty (DMEK) shows a low complication rate, with most adverse events being asymptomatic. This advanced corneal transplant technique offers excellent visual outcomes and is becoming as safe as Descemet stripping automated endothelial keratoplasty.

Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Transplantation

Background:

  • Descemet membrane endothelial keratoplasty (DMEK) is an advanced endothelial keratoplasty technique.
  • Understanding its complication profile is crucial for surgical adoption.

Observation:

  • A retrospective case series reviewed 75 eyes undergoing DMEK by a single surgeon.
  • Exclusion of the surgeon's initial 50 cases ensured a focus on established surgical proficiency.

Findings:

  • The majority of complications, such as peripheral donor scrolls (17/75), were asymptomatic.
  • Primary graft failure (2/75) and rebubbling (2/75) had low success rates, though repeat DMEK was effective.
  • No severe complications like pupillary block glaucoma or free-floating donors were observed.

Implications:

  • DMEK demonstrates a favorable safety profile, comparable to Descemet stripping automated endothelial keratoplasty.
  • High rates of visual recovery (20/25 by 3 months) and endothelial cell survival support DMEK's efficacy.

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