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Mechanical activation of pharmaceutical systems.
R Hüttenrauch1, S Fricke, P Zielke
1Department of Research and Development, VEB JENAPHARM, Otto-Schott-Straβe 13, DDR-6900, Jena.
Pharmaceutical Research
|November 26, 2013
Summary
Mechanical activation in pharmaceutics transforms stored energy into chemical energy. This study optimizes milling and tabletting processes by evaluating energy transformation and activity using the Eyring equation.
Area of Science:
- Pharmaceutical Science
- Physical Chemistry
- Materials Science
Background:
- Mechanical activation is increasingly significant in pharmaceutical processing.
- Understanding energy transformation during mechanical processes is crucial for drug development.
Purpose of the Study:
- To quantify the mechanical activation induced by pharmaceutical processes.
- To evaluate the transformation of stored energy into chemical energy and free enthalpy.
- To compare different milling and tabletting techniques.
Main Methods:
- Utilized the Eyring equation to analyze the rate of an indicator reaction.
- Measured the transformation of structurally stored energy into chemical energy.
- Assessed implied free enthalpy and excess free enthalpy (activity).
Main Results:
- Quantified the extent of activation for various milling and tabletting methods.
- Determined the relationship between mechanical processes and energy transformation.
- Identified optimal conditions for pharmaceutical mechanical activation.
Conclusions:
- Mechanical activation significantly impacts pharmaceutical processes.
- The Eyring equation provides a valuable tool for evaluating energy transformation and activity.
- Optimization of milling and tabletting processes can enhance drug formulation.
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