Association between the TP53 polymorphisms and lung cancer risk: a meta-analysis

Area of Science:

• Genetics
• Oncology
• Molecular Epidemiology

Background:

• The association between TP53 gene polymorphisms and lung cancer risk is debated.
• Previous studies on TP53 codon 72, intron 6, and intron 3 16 bp polymorphisms have yielded controversial results.
• A comprehensive meta-analysis is required to clarify these associations.

Purpose of the Study:

• To precisely estimate the relationship between TP53 codon 72, intron 6, and intron 3 16 bp polymorphisms and lung cancer risk.
• To synthesize existing evidence through a meta-analysis of published literature.
• To identify potential risk associations across different genetic models and subgroups.

Main Methods:

• A systematic literature search was conducted to identify relevant studies.
• Meta-analysis was performed on 38 publications comprising 51 studies.
• Data included 17,337 cases and 16,127 controls for codon 72, 2,201 cases and 2,399 controls for intron 6, and 4,322 cases and 4,558 controls for intron 3 16 bp.

Main Results:

• TP53 codon 72 polymorphism showed a significant association with increased lung cancer risk across all genetic models (dominant, recessive, additive).
• TP53 intron 6 polymorphism was significantly associated with increased lung cancer risk under the dominant model.
• TP53 intron 3 16 bp polymorphism demonstrated significant associations in dominant and additive models, though sensitivity analysis indicated potential variability.

Conclusions:

• TP53 codon 72 and intron 6 polymorphisms are associated with an elevated risk of lung cancer.
• The findings suggest a role for these TP53 variants in lung carcinogenesis.
• Larger studies are recommended to investigate gene-environment interactions concerning TP53 polymorphisms and lung cancer risk.