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Lipid Bilayer Vesicle Generation Using Microfluidic Jetting
Published on: February 21, 2014
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Formation of multilayered vesicles from water/organic-solvent (w/o) emulsions: theory and practice
C Pidgeon1, A H Hunt, K Dittrich
1Eli Lilly Research Laboratories, Indianapolis, Indiana, 46285.
Pharmaceutical Research
|November 26, 2013
Abstract:
Multilayered liposome (MLV) formation from water/organic-solvent (W/O) emulsions was studied. A fundamental liposome population parameter, the E(ratio), was defined and used to estimate the bilayer number and water spacing in MLV liposomes. MLVs prepared from W/O emulsions have optimum drug entrapment at an emulsion-lipid/emulsion-water ratio of ∼0.33. Drug entrapment is typically 50 to 65% under these optimal conditions.
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