[Induction of Ca2+ ion transport in human thrombocytes as affected by thyroid hormone receptors from malignant transformed cells]
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Updated: Aug 15, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Abstract:
The effect of thyroid hormone receptors isolated from normal and malignant cells on the induction of Ca2+ transport to platelets was studied. It is established that the receptor isolated from malignant cells by thyroxin (T4) or triiodothyronine (T3) stimulates (three-fold) the induction of Ca2+ transport to platelets. The effect is blocked by verapamil, which is the inhibitor of Ca2+ channels in plasma membranes. It is shown that neither the receptor of cancer cells, nor hormones (T3 or T4) influence the transport of Ca2+ to platelets without preliminary complexing. The hormone-receptor complex failed to affect the concentration of "cytoplasmic" Ca2+ in platelets analogous experimental conditions. It is suggested that the increased Ca2+ content in cancer cells can be partially attributed to the ability of thyroid hormone receptor of cancer cells to induce Ca2+ transport across the plasma membrane.
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