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Development of Interferon Suppositories. I. Enhanced Rectal Absorption of Human Fibroblast Interferon by Fusogenic
H Yoshikawa1, K Takada, Y Satoh
1Department of Biopharmaceutics, Kyoto Pharmaceutical University, Kyoto, Japan.
Abstract:
We attempted to enhance the rectal absorption of human fibroblast interferon (HuIFN-β) in rats by the administration of suppositories containing fusogenic lipid and a nontoxic surfactant. Suppositories containing either the lipid (linoleic acid) or the surfactant [HCO60; polyoxyethylated (60 mol) hydrogenated castor oil] alone failed to enhance the absorption of HuIFN-β. However, suppositories containing both linoleic acid and HCO60 facilitated the rectal absorption of HuIFN-β. The absorbed HuIFN-β was selectively delivered via the lymph.
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