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The effects of alcohol on cyclic AMP in mouse brain
E K Orenberg1, J Renson, J D Barchas
1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 94305, Stanford, California.
Abstract:
Detailed analysis of the dose-response and time-course relationship of ethanol to changes in adenosine 3',5'-cyclic monophosphate (cAMP) content of mouse brain revealed several patterns of response, including both decreases and increases depending on brain area. Whole-brain cAMP content was decreased with ethanol injection at all doses (0.4-3.2 g/kg), and reflected the decreased levels in the cortex. The subcortical and cerebellar levels underwent a significant increase with doses of 1.6 and 3.2 g/kg, respectively. In all brain areas, significant changes in cAMP content occur within 10 min after ethanol injection; elevated levels persist for 30-60 min in the subcortex and cerebellum, but remain significantly depressed in the cortex at 3 h. These dynamic changes in brain cAMP levels after ethanol administration may reflect variations in neurotransmitter activity.
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