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T Cell Types and Functions01:24

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Related Experiment Video

Updated: May 5, 2026

Isolation and Characterization of Neutrophils with Anti-Tumor Properties
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Neutrophils suppress γδ T-cell function.

Florencia Sabbione1, María L Gabelloni, Glenda Ernst

  • 1Instituto de Medicina Experimental (IMEX) CONICET - Academia Nacional de Medicina, Buenos Aires, Argentina.

European Journal of Immunology
|November 26, 2013
PubMed
Summary

Neutrophils suppress the function of gamma delta T cells, inhibiting their activation and proliferation. This neutrophil-mediated suppression, driven by reactive oxygen species, suggests a role in resolving inflammation.

Keywords:
NeutrophilsROSγδ T cells

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Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • Gamma delta (γδ) T cells are known to activate neutrophils via cytokines.
  • The reciprocal interaction between neutrophils and γδ T cells is less understood.

Purpose of the Study:

  • To investigate the suppressive effect of human neutrophils on human blood γδ T cells.
  • To elucidate the mechanisms underlying neutrophil-mediated γδ T cell suppression.

Main Methods:

  • Co-culture of human neutrophils and γδ T cells.
  • Assessment of γδ T cell activation markers (CD25, CD69), IFN-γ production, and proliferation.
  • Inhibition studies using prostaglandin E2, arginase I, and catalase.
  • Experiments with xanthine/xanthine oxidase system and neutrophils from chronic granulomatous disease patients.

Main Results:

  • Neutrophils significantly inhibited γδ T cell activation, IFN-γ production, and proliferation.
  • Neutrophil-induced suppression was prevented by catalase, implicating reactive oxygen species (ROS).
  • Neutrophils from chronic granulomatous disease patients showed reduced suppressive capacity.

Conclusions:

  • Human neutrophils suppress the function of human γδ T cells.
  • Neutrophil-derived ROS are key mediators of this suppression.
  • This interaction represents a bi-directional crosstalk, with neutrophils contributing to inflammation resolution by suppressing γδ T cells.