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Updated: May 5, 2026

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC Crosslinking of Small Molecules to Isolate Chromatin
Published on: January 20, 2016
Polyamine-DNA Interactions: Possible Site of New Cancer Chemotherapeutic Intervention
1Department of Laboratory Medicine, School of Medicine, University of California, San Francisco, California, 94143.
Abstract:
The effects of polyamines on the structure of nucleic acids in cell-free systems and in cell culture systems are reviewed. Evidence suggests that polyamine depletion inhibits cell growth and may cause conformational changes in DNA. These effects may be exploited to cause changes in the action of drugs and may be used to advantage in combination treatment protocols. A discussion of theoretical models of the interactions, physicochemical evidence for conformational changes, and the effects of anticancer drugs in cells depleted of polyamines is presented.
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