Related Experiment Video
Updated: May 5, 2026

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient
Published on: September 3, 2014
Proteins of the synaptic membrane
1Brain Research Group, Chemistry Department, Indiana University, 47401, Bloomington, Indiana.
Abstract:
The purpose of this communication is to provide a survey of contempory information concerning the composition, disposition, and functional significance of proteins in or on synaptic membranes derived from rat brain synaptosomes. Special emphasis is placed on their content of glycoproteins, fibrous proteins, proteins susceptible to rapid phosphorylation and dephosphorylation, and receptors for various putative neurotransmitters. Their nature, localization, possible interactions, and potential function in synaptic transmission are discussed.
Related Concept Videos
Fusion of Secretory Vesicles with the Plasma Membrane
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
Membrane Proteins
Membrane Proteins
Protein Translocation Machinery on the ER Membrane
Sec61 protein conducting channel
In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the...
Introduction to Membrane Proteins
SNAREs and Membrane Fusion
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...

