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Updated: May 5, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Synthesis of enantiomeric pureCis-dichloroplatinum(II) amino acid complexes
D Dalietos1, A Furst, D Theodoropoulos
1Institute of Chemical Biology, University of San Francisco, 94117, San Francisco, CA, USA.
Abstract:
The reaction of potassium tetrachloroplatinate(II) with six representative sulfurcontaining amino acids, namely,D- andL-cysteine,D- andL-methionine and its methyl ester hydrochloride gives the corresponding enantiomerically purecis-dichloroplatinum(II) complexes. This represents the first reported series of well-characterized enantiomerically pure platinum(II) complexes for bothD- andL-amino acids.The spectroscopic properties, including IR,(1)H-NMR, and(13)C NMR, of these complexes and their configuration are discussed.
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