Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

Factors Influencing Drug Absorption: Physicochemical Parameters

Factors Influencing Drug Absorption: Physicochemical Parameters

The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Insula and orbitofrontal cortical morphology in substance dependence is modulated by sex.

AJNR. American journal of neuroradiology·2012

Same author

Modelling formulations using gene expression programming--a comparative analysis with artificial neural networks.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2011

Same author

Effect of crystallisation conditions and feedstock morphology on the aerosolization performance of micronised salbutamol sulphate.

International journal of pharmaceutics·2011

Same author

Comminution of ibuprofen to produce nano-particles for rapid dissolution.

International journal of pharmaceutics·2011

Same author

The impact of material attributes and process parameters on the micronisation of lactose monohydrate.

International journal of pharmaceutics·2011

Same author

Design of a fixed-dose paediatric combination of artesunate and amodiaquine hydrochloride.

International journal of pharmaceutics·2009

Same journal

Leveraging Carnitine-functionalized Lipid Nanocarrier based Targeted Delivery of A1874 PROTAC for Glioblastoma.

Pharmaceutical research·2026

Same journal

Impact of Febrile State on Vancomycin Clearance in Pediatric Patients: Insights From Population Pharmacokinetic Modeling.

Pharmaceutical research·2026

Same journal

Sustained Intra-Articular Delivery of Triple Therapeutics Using a Phase-Transition Phospholipid-Based Gel for Effective Treatment of Gouty Arthritis.

Pharmaceutical research·2026

Same journal

Spray Dried Lysozyme Microspheres: Morphological Evolution and Enzymatic Activity Retention.

Pharmaceutical research·2026

Same journal

Colloidal Stability of Amorphous Nanoparticles in Solution: Impact of Stabilizer.

Pharmaceutical research·2026

Same journal

Impact of Mixing Approach and Bubble Formation on In Situ Forming Implant Properties.

Pharmaceutical research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 5, 2026

Diffuse Reflectance Infrared Spectroscopic Identification of Dispersant/Particle Bonding Mechanisms in Functional Inks

Diffuse Reflectance Infrared Spectroscopic Identification of Dispersant/Particle Bonding Mechanisms in Functional Inks

Published on: May 8, 2015

Interaction Phenomena in some Aqueous-Based Tablet Coating Polymer Systems.

A O Okhamafe¹, P York

¹Postgraduate School of Studies in Pharmacy, University of Bradford, Bradford, BD7 1DP, UK.

Pharmaceutical Research

|November 26, 2013

Summary

This summary is machine-generated.

Water-based tablet coatings containing hydroxypropyl methylcellulose (HPMC) and additives like polyvinyl alcohol (PVA) or polyethylene glycol (PEG) were studied. Results show water hinders polymer interaction, with PEG acting as a plasticizer and PVA increasing film crystallinity.

More Related Videos

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Related Experiment Videos

Last Updated: May 5, 2026

Diffuse Reflectance Infrared Spectroscopic Identification of Dispersant/Particle Bonding Mechanisms in Functional Inks

Diffuse Reflectance Infrared Spectroscopic Identification of Dispersant/Particle Bonding Mechanisms in Functional Inks

Published on: May 8, 2015

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Area of Science:

Materials Science
Polymer Chemistry
Pharmaceutical Technology

Background:

Tablet film coatings are crucial for drug delivery and stability.
Understanding polymer interactions in aqueous coating systems is essential for formulation development.

Purpose of the Study:

To investigate molecular interactions in hydroxypropyl methylcellulose (HPMC) based film coatings.
To evaluate the effects of polyvinyl alcohol (PVA) and polyethylene glycol (PEG) 400/1000 as additives.
To determine the compatibility and thermal properties of these polymer blends.

Main Methods:

Viscometry was employed to assess polymer-polymer interactions in solution.
Differential Scanning Calorimetry (DSC) was used to analyze film crystallinity and glass transition temperatures (Tg).

Main Results:

Water acted as an inhibitor of polymer-polymer interactions, with effect intensity linked to polymer solubility.
Polyethylene glycol (PEG) 400 and PEG 1000 demonstrated plasticizer effects on HPMC, lowering its Tg.
Polyvinyl alcohol (PVA) increased HPMC's Tg, indicating partial crystallinity in HPMC/PVA blends.

Conclusions:

Maximum compatibility limits were determined: 40 wt% for PVA, 20 wt% for PEG 400, and 15 wt% for PEG 1000 in HPMC blends.
The study elucidates the distinct roles of PVA and PEG in modifying the thermal and interaction properties of HPMC coatings.
Findings provide valuable insights for optimizing aqueous-based tablet coating formulations.