Synthesis of 1,2,3-triazolyl nucleoside analogs as potential anti-influenza A (H3N2 subtype) virus agents
Hanane Elayadi1, Michael Smietana, Jean J Vasseur
1Unité de Chimie Biomoléculaire et Médicinale, Laboratoire de Chimie Biomoléculaire Substances Naturelles et Réactivité (URAC 16), Faculty of Science Semlalia, Marrakech, Morocco.
Archiv Der Pharmazie
|November 26, 2013
Abstract:
Montmorillonite K10 impregnated with copper dichloride and potassium iodide (CuCl2 /KI/K10) was used as catalyst in the cycloaddition of azides and propargylnucleobases, to provide the corresponding 1,4-disubstituted 1,2,3-triazoles in good yield. All compounds 16-23 were evaluated for their antiviral activity in vitro. Compound 18 showed moderate inhibition against influenza virus A (H3N2).
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