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Synthesis and retention of methotrexate polyglutamates in Ehrlich ascites carcinoma cells
Drugs Under Experimental and Clinical Research
|January 1, 1986
Abstract:
The formation of methotrexate (MTX) polyglutamates in Ehrlich ascites carcinoma parental and 5-fluorodeoxy-uridine (FdUrd)-resistant cells was examined. The prolonged retention of methotrexate in noneffluxable-polyglutamate form and the pharmacological application of this process is discussed.