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Increased neural response to peer rejection associated with adolescent depression and pubertal development

Jennifer S Silk1, Greg J Siegle2, Kyung Hwa Lee3

  • 1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20895, USA, Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02903, USA, and School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20895, USA, Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02903, USA, and School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA silkj@upmc.edu.

Social Cognitive and Affective Neuroscience
|November 26, 2013
PubMed
Summary

Adolescents with major depressive disorder (MDD) show heightened brain responses to peer rejection. This heightened sensitivity to social evaluation is linked to pubertal development but is especially pronounced in youth experiencing depression.

Keywords:
adolescencedepressionneuroimagingrejectionsocial exclusion

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