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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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GABA(A) receptor modulation by terpenoids from Sideritis extracts

Artur Kessler1, Hilal Sahin-Nadeem, Sarah C R Lummis

  • 1Department of Chemistry and Pharmacy, Food Chemistry Division, University of Erlangen-Nuernberg, Erlangen, Germany.

Molecular Nutrition & Food Research
|November 26, 2013
PubMed
Summary

Sideritis extracts modulate GABAA receptors. Researchers identified specific terpenes like carvacrol, isopulegol, and pinocarveol as potent modulators, acting independently of the gamma-2 subunit.

Keywords:
GABAA receptorPatch clamp recordingsTerpeneTwo-electrode voltage clamp recordingsVolatile odorants

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