Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

5.0K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.0K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

3.0K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.0K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

3.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
3.8K
Stem Cell Culture01:17

Stem Cell Culture

4.5K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
4.5K
Embryonic Stem Cells00:58

Embryonic Stem Cells

25.9K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
25.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tenofovir-Diphosphate and Emtricitabine-Triphosphate Adherence Benchmarks in Dried Blood Spots for Persons With HIV Receiving Tenofovir Alafenamide and Emtricitabine-Based Antiretroviral Therapy (QUANTI-TAF).

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2024
Same author

Recognition and Management of Hospital-Acquired Sepsis Among Older General Medical Inpatients: A Multi-Site Retrospective Study.

International journal of general medicine·2023
Same author

AQP5 enriches for stem cells and cancer origins in the distal stomach.

Nature·2020
Same author

Vasoplegic syndrome following cardiothoracic surgery-review of pathophysiology and update of treatment options.

Critical care (London, England)·2020
Same author

Inhalation therapy in the next decade: Determinants of adherence to treatment in asthma and COPD.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace·2018
Same author

Lgr5 marks stem/progenitor cells in ovary and tubal epithelia.

Nature cell biology·2014

Related Experiment Video

Updated: May 5, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

12.5K

Engineering the niche for stem cells.

Shawna Tan1, Nicholas Barker

  • 1A*STAR Institute of Medical Biology , 8A Biomedical Grove, 06-06 Immunos , Singapore .

Growth Factors (Chur, Switzerland)
|November 27, 2013
PubMed
Summary

Creating artificial stem cell niches is key for regenerative medicine. Advanced bioengineering enables precise control over these niches for better therapies and research.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Adult stem cells require specific microenvironments for function.
  • Developing artificial stem cell niches is crucial for advancing regenerative medicine therapies.
  • Current therapy development has been slow despite stem cells' potential.

Purpose of the Study:

  • To summarize approaches and tools for recreating stem cell niches.
  • To explore recent advances in bioengineering stem cell niches.
  • To highlight the integration of engineering and biology for clinical applications.

Main Methods:

  • Review of existing bioengineering techniques and platforms for niche creation.
  • Analysis of technological innovations enabling higher resolution and specificity.

More Related Videos

Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation
09:51

Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation

Published on: February 2, 2016

14.1K
Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

11.7K

Related Experiment Videos

Last Updated: May 5, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

12.5K
Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation
09:51

Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation

Published on: February 2, 2016

14.1K
Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

11.7K
  • Examination of stem cell niche recreation in intestinal, hematopoietic, and epidermal tissues.

    • Main Results:

    • Bioengineering offers tools to create functional, artificial stem cell niches.
    • Technological advancements allow for higher resolution and specificity in niche engineering.
    • Multidisciplinary integration is progressing towards clinically exploitable niche generation.

    Conclusions:

    • Artificial stem cell niches are essential for multipotency, differentiation, and proliferation.
    • Advanced bioengineering is critical for developing effective regenerative medicine therapies.
    • The integration of engineering and biology promises clinical translation of stem cell technologies.