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[Profilins: allergens with clinical relevance].

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Profilins are key allergens causing cross-reactivity in pollen-allergic individuals, leading to reactions from fruits and vegetables. These underrated panallergens are crucial in understanding latex-pollen-fruit allergy and oral allergy syndrome.

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Area of Science:

  • Protein biochemistry
  • Immunology
  • Allergology

Context:

  • Profilins are conserved eukaryotic proteins vital for actin dynamics.
  • Allergic reactions to pollen often extend to plant-derived foods, a phenomenon known as latex-pollen-fruit allergy.
  • Profilins act as panallergens, implicated in at least 20% of pollen allergies and oral allergy syndrome (OAS).

Purpose:

  • To highlight the significant role of profilins in sensitizing individuals with plant, fruit, and pollen allergies.
  • To analyze the amino acid sequences of allergenic profilins.
  • To underscore the importance of profilins in cross-reactivity.

Summary:

  • Analysis of allergenic profilin sequences reveals high identity (70-85%) between plant profilins.
  • This sequence homology explains the cross-reactivity observed in patients allergic to pollen, fruits, and vegetables.
  • Profilins are identified as significant, yet often underestimated, allergens contributing to cross-reactivity.

Impact:

  • Increased clinical awareness of profilins as common allergens and panallergens.
  • Improved understanding of the mechanisms behind oral allergy syndrome (OAS) and latex-pollen-fruit allergy.
  • Potential for better diagnostic and therapeutic strategies for patients with profilin allergies.