Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

5.7K
Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
5.7K
Recrystallization: Solid–Solution Equilibria01:10

Recrystallization: Solid–Solution Equilibria

4.1K
Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Structural Enthalpy in Spherical Nucleic Acid Hybridization.

Journal of the American Chemical Society·2018
Same author

The Weak-Link Approach to the Synthesis of Inorganic Macrocycles.

Angewandte Chemie (International ed. in English)·2018
Same author

Ligand Design for Electrochemically Controlling Stoichiometric and Catalytic Reactivity of Transition Metals.

Angewandte Chemie (International ed. in English)·2018
Same author

The Electrical Properties of Gold Nanoparticle Assemblies Linked by DNA.

Angewandte Chemie (International ed. in English)·2018
Same author

Directed Assembly of Periodic Materials from Protein and Oligonucleotide-Modified Nanoparticle Building Blocks.

Angewandte Chemie (International ed. in English)·2018
Same author

PLGA Spherical Nucleic Acids.

Advanced materials (Deerfield Beach, Fla.)·2018

Related Experiment Video

Updated: May 5, 2026

Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
09:15

Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering

Published on: August 14, 2018

12.2K

Growth dynamics for DNA-guided nanoparticle crystallization.

Subas Dhakal1, Kevin L Kohlstedt, George C Schatz

  • 1Department of Materials Science and Engineering and ‡Department of Chemistry, Northwestern University , Evanston, Illinois 60208, United States.

ACS Nano
|November 27, 2013
PubMed
Summary

Spherical nucleic acid (SNA) nanostructures form crystalline superlattices. Larger SNAs exhibit faster coalescence due to enhanced surface diffusion, impacting crystallite growth dynamics.

More Related Videos

Optimizing the Growth of Endothiapepsin Crystals for Serial Crystallography Experiments
09:52

Optimizing the Growth of Endothiapepsin Crystals for Serial Crystallography Experiments

Published on: February 4, 2021

3.9K
Optimization of Crystal Growth for Neutron Macromolecular Crystallography
12:29

Optimization of Crystal Growth for Neutron Macromolecular Crystallography

Published on: March 13, 2021

6.6K

Related Experiment Videos

Last Updated: May 5, 2026

Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
09:15

Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering

Published on: August 14, 2018

12.2K
Optimizing the Growth of Endothiapepsin Crystals for Serial Crystallography Experiments
09:52

Optimizing the Growth of Endothiapepsin Crystals for Serial Crystallography Experiments

Published on: February 4, 2021

3.9K
Optimization of Crystal Growth for Neutron Macromolecular Crystallography
12:29

Optimization of Crystal Growth for Neutron Macromolecular Crystallography

Published on: March 13, 2021

6.6K

Area of Science:

  • Nanotechnology
  • Materials Science
  • Biophysics

Background:

  • Spherical nucleic acid (SNA) nanostructures self-assemble into crystalline superlattices via DNA hybridization.
  • SNA crystallites form during assembly and coalesce into polycrystalline materials through coarsening.

Purpose of the Study:

  • Investigate the growth dynamics of SNA crystallites into body-centered cubic superlattices.
  • Analyze the coalescence of SNA aggregates using a colloidal model.
  • Understand the role of electrostatic repulsions and DNA attractions in SNA assembly.

Main Methods:

  • Developed a colloidal model balancing electrostatic core repulsions and DNA hybridization attractions.
  • Applied power law analysis to describe SNA crystallite growth.
  • Utilized molecular dynamics simulations to study coalescence mechanisms.

Main Results:

  • Isolated SNA crystallite growth follows a t(1/2) power law, consistent with experiments.
  • Coalescence dynamics are significantly influenced by the misorientation angle between crystallites.
  • Grain rotation induced coalescence and neck coarsening were observed.
  • Larger SNAs demonstrate faster coalescence due to increased surface diffusion.

Conclusions:

  • SNA crystallite growth and coalescence are governed by a balance of forces and geometric factors.
  • The misorientation angle and SNA size are critical parameters influencing coalescence.
  • Findings offer fundamental insights into nanoparticle surface chemistry and its impact on material properties.