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Related Experiment Video

Updated: May 5, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

Inflammasomes and metabolic disease.

Jorge Henao-Mejia¹, Eran Elinav, Christoph A Thaiss

¹Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520;

Annual Review of Physiology

|November 27, 2013

Summary

Inflammasomes are key sensors of metabolic changes, linking obesity and immune responses. Understanding this connection is crucial for addressing prevalent metabolic diseases.

Area of Science:

Immunology
Metabolic pathways
Physiology

Background:

Innate immunity and metabolism are conserved and integrated for survival.
Metabolic diseases, particularly obesity, are rising globally.
Obesity highlights the role of innate immunity in metabolic dysfunction.

Purpose of the Study:

To review evidence on inflammasomes in metabolic diseases.
To highlight inflammasomes as sensors of metabolic perturbations.

Main Methods:

Literature review of recent evidence.

Main Results:

Inflammasomes critically sense metabolic changes in various tissues.
Inflammasomes play a role in the progression of common metabolic diseases.

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Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

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Conclusions:

Inflammasomes are central to the pathophysiology of obesity-related metabolic diseases.
Targeting inflammasomes may offer therapeutic strategies for metabolic disorders.