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Updated: May 5, 2026
06:09
Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
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Breathing intolerance index in healthy infants
Hisaya Hasegawa1, Nobuhide Henmi, Shio Tsuruta
1Division of Neonatal Intensive Care, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
Summary
The breathing intolerance index (BITI) in healthy infants was found to be significantly higher than in adults. This study establishes a normal BITI range for infants, aiding in respiratory assessments.
Area of Science:
- Pediatric respiratory physiology
- Pulmonary function testing
Background:
- The breathing intolerance index (BITI) is a measure used to guide ventilator use in adults with respiratory conditions.
- In ventilated adults, BITI typically exceeds 0.15.
- Healthy adults exhibit mean BITI values of 0.050 ± 0.009 (upright) and 0.057 ± 0.016 (supine).
Purpose of the Study:
- To establish normal reference values for the breathing intolerance index (BITI) in healthy infants.
- To compare infant BITI values with those previously reported for adults.
Main Methods:
- Thirty healthy infants were assessed in a supine position.
- BITI was calculated using the formula: BITI = (Ti/Ttot) × (TV/VC), where Ti is inspiratory time, Ttot is total breath cycle duration, TV is tidal volume, and VC is vital capacity.
- Tidal volume and Ti/Ttot were measured during resting tidal breathing, and vital capacity was determined spirometrically.
Main Results:
- The mean BITI in healthy, supine infants was 0.120 ± 0.013.
- Infant BITI values were significantly higher compared to adult BITI values.
Conclusions:
- This study successfully measured BITI in a cohort of healthy infants.
- Further research is required to ascertain the clinical significance and utility of BITI in pediatric respiratory care.
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