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Updated: May 5, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Autoimmune thyroiditis: Centennial jubilee of a social disease and its comorbidity
L P Churilov1, Yu I Stroev1, I Yu Serdyuk1
1Medical Faculty, Saint Petersburg State University, Russia.
Abstract:
The history of autoimmune thyroiditis (AIT) and its role in pathophysiology of transition from adolescent hypothalamic syndrome (obesity with rose striae) into early metabolic syndrome is reviewed. Marfanoid phenotype and chronic disequilibrium between local, autacoid-mediated and systemic, hormone-mediated regulation, typical for inherited connective tissue disorders, may promote this transition. Pathogenetic roles of hyperprolactinemia and cytokine misbalance are evaluated and discussed in its pathogenesis.
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