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Guideline-adherent therapy in patients with cardiovascular diseases in Taiwan
Jiann-Shing Jeng1, Wei-Hsian Yin2, Chin-Chou Huang3
1Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
Insights
Achieving lipid and blood pressure targets in Taiwanese patients with cardiovascular diseases remains suboptimal, especially for those with cerebrovascular disease and women. Enhanced efforts are needed to meet guideline recommendations for secondary prevention.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Cardiovascular diseases (CVD) and coronary artery disease (CAD) necessitate aggressive risk factor management to prevent secondary comorbidities.
- Guideline recommendations exist for lipid and blood pressure (BP) control in these high-risk patients.
Purpose of the Study:
- To evaluate the adherence to guideline-recommended lipid and BP control targets in patients with established CVD, CAD, or both in Taiwan.
Main Methods:
- A multicenter cohort study involving 3316 outpatients with CVD and/or CAD across 14 hospitals in Taiwan.
- Comparison of risk factors (lipids, BP, diabetes) and medication use between patient groups.
- Analysis of achievement rates for lipid and BP control targets.
Main Results:
- Only 54.8% and 55.9% of patients achieved recommended lipid and BP targets, respectively.
- Patients with cerebrovascular disease (CVD) were older, had higher hypertension rates, and were less likely to achieve targets (aOR 0.61).
- Women were also less likely to achieve recommended lipid and BP targets (aOR 0.65).
Conclusions:
- Guideline-recommended lipid and BP control targets are suboptimal in Taiwanese patients with CAD and CVD.
- Target achievement requires greater clinical focus, particularly for patients with CVD and for women.
Background/Purpose:
Aggressive and persistent control of risk factors is recommended for prevention of secondary comorbidities in patients with cardiovascular diseases. This study aimed to evaluate guideline recommendations for achieving targets for lipid and blood pressure (BP) control in patients with cardiovascular diseases in Taiwan.
Methods:
This multicenter cohort study was conducted in 14 hospitals in Taiwan. A total of 3316 outpatients who had established cerebrovascular disease (CVD), coronary artery disease (CAD), or both were recruited. Risk factors for comorbid conditions such as high BP, sugar, hemoglobin A1C, abnormal lipids, lipoproteins, and medication use were compared between patients with CVD, CAD, or both.
Results:
Of all patients, 503 (15.2%) had CVD only, 2568 (77.4%) had CAD only, and 245 (7.4%) had both CVD and CAD. Compared with patients who had only CAD, those with CVD were older, had higher frequency of hypertension, and lower frequency of diabetes mellitus. Patients with CAD were more likely to receive lipid-lowering and antihypertensive drugs than those with CVD (p < 0.001). Only 54.8% and 55.9% of patients achieved the recommended lipid and BP control targets, respectively. Patients with CVD (adjusted odds ratio: 0.61; 95% confidence interval: 0.48-0.78; p < 0.001) and women (adjusted odds ratio: 0.65; 95% confidence interval: 0.55-0.78; p < 0.001) were less likely to achieve the recommended lipid and BP targets.
Conclusion:
The guideline-recommended targets for lipids and BP in patients with CAD and CVD were still suboptimal in Taiwan. Greater efforts are required to achieve the targets, particularly in patients with CVD and in women.
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