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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
358
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
400
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
387
Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

376
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Related Experiment Video

Updated: May 5, 2026

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
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Iron status in the elderly.

Susan J Fairweather-Tait1, Anna A Wawer1, Rachel Gillings1

  • 1Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK.

Mechanisms of Ageing and Development
|November 27, 2013
PubMed
Summary
This summary is machine-generated.

Iron deficiency anaemia is common in older adults, influenced by inflammation and diet. Personalized management is key to prevent iron deficiency or overload in this age group.

Keywords:
AnaemiaDietary intakeElderlyIron statusIron stores

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Area of Science:

  • Gerontology
  • Hematology
  • Nutritional Science

Background:

  • Iron deficiency anaemia (IDA) is highly prevalent in individuals over 80.
  • Ageing may not inherently cause iron store depletion, but chronic inflammation and elevated hepcidin levels contribute to systemic iron depletion in older adults.
  • Poor diet and medications like aspirin are additional factors impacting iron status.

Purpose of the Study:

  • To explore the complex factors contributing to iron deficiency anaemia in the elderly population.
  • To discuss the challenges in assessing iron status in older adults due to chronic inflammation.
  • To review potential adverse effects of iron supplementation and the role of iron in age-related diseases.

Main Methods:

  • Literature review and synthesis of existing research on iron metabolism in ageing.
  • Analysis of factors affecting iron status, including inflammation, diet, and medication.
  • Discussion of the implications of iron dysregulation in age-related conditions.

Main Results:

  • Serum ferritin declines with age, but iron stores are not necessarily depleted.
  • Chronic inflammation and elevated hepcidin are significant contributors to iron deficiency in older adults.
  • Anaemia in older age is linked to adverse outcomes like falls and depression.

Conclusions:

  • Managing iron deficiency in older adults requires a personalized approach, considering individual factors.
  • Potential risks of iron supplements, including inflammation and tissue deposition, need careful consideration.
  • The relationship between brain iron levels and age-related diseases requires further investigation.