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Sensitivity testing of the Seizure Severity Questionnaire (SSQ).
Simon Borghs1, Christine de la Loge2, Yves Brabant3
1UCB Pharma, Slough, UK.
Epilepsy & Behavior : E&B
|November 27, 2013
Summary
The Seizure Severity Questionnaire (SSQ) effectively measures treatment effects in patients with partial-onset seizures. It demonstrated sensitivity in distinguishing between responders and nonresponders for complex partial seizures and secondarily generalized partial seizures.
Area of Science:
- Neurology
- Clinical Trials
- Patient-Reported Outcomes
Background:
- The Seizure Severity Questionnaire (SSQ) assesses seizure impact.
- Evaluating SSQ sensitivity is crucial for its clinical utility in epilepsy research.
Purpose of the Study:
- To evaluate the sensitivity of the SSQ in detecting treatment effects.
- To validate the SSQ's ability to differentiate seizure severity between patient groups.
Main Methods:
- Pooled data from open-label extensions of two clinical trials were analyzed.
- SSQ item changes from baseline were compared between responders and nonresponders.
- Patients were stratified by seizure type: complex partial seizures (CPS) and secondarily generalized partial seizures (SGPS).
Main Results:
- The SSQ total score and specific items (ictal movement, consciousness, postictal effects, emotional effects) differentiated responders from nonresponders.
- Significant differences were observed in both CPS and SGPS patient groups.
- The SSQ demonstrated sensitivity in capturing treatment-related changes.
Conclusions:
- The Seizure Severity Questionnaire (SSQ) is a sensitive tool for evaluating treatment effects in partial-onset seizures.
- These findings further validate the SSQ's utility in clinical trials and patient care.
- The SSQ effectively captures clinically meaningful differences in seizure experiences.
