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Hematological parameters in patients of cleft lip and cleft palate with special reference to eosinophil counts
Shipra Singhal1, Gita Negi, Harish Chandra
1From the *Departments of Pathology; and †Plastic Surgery, Himalayan Institute of Medical Sciences, Dehradun, India.
Insights
Cleft lip and palate patients often have high eosinophil counts, which can delay surgery. This study highlights the prevalence of anemia and eosinophilia in these patients, emphasizing the value of absolute eosinophil count for assessment.
Area of Science:
- Hematology
- Pediatric Surgery
- Congenital Abnormalities
Background:
- Cleft lip and palate affect approximately 1.4 per 1000 live births in India.
- These conditions are frequently associated with eosinophilia, potentially delaying necessary surgical interventions.
- Understanding hematological profiles is crucial for managing these patients.
Purpose of the Study:
- To investigate the hematological parameters in individuals diagnosed with cleft lip and palate.
- To identify common hematological abnormalities in this patient cohort.
Main Methods:
- A study involving 223 patients with cleft lip and palate.
- Analysis of key hematological parameters: hemoglobin, total leukocyte count, differential leukocyte count, absolute eosinophil count, and red cell indices.
Main Results:
- Anemia was prevalent in 81.63% (182/223) of cases, predominantly microcytic hypochromic.
- Eosinophilia was observed in 20.60% (46/223) of the studied patients.
Conclusions:
- A significant proportion of patients with cleft lip and palate exhibit elevated eosinophil counts.
- Absolute eosinophil count is identified as a more effective parameter for evaluating eosinophil levels in this population.
Introduction:
Birth abnormalities like cleft lip and cleft palate account for about 1.4 per 1000 live births in India. These are seen to be associated with a high incidence of eosinophilia which delays the surgical management of these patients.
Aims:
The aim of this paper is to study the hematological parameters in patients of cleft lip and cleft palate.
Patients And Methods:
A total of 223 cases of cleft lip and cleft palate were taken up for the study. Hematological parameters including hemoglobin, total leukocyte count, differential leukocyte count, absolute eosinophil count, and red cell indices were studied.
Results:
Anemia was found in 182/223 (81.63%) cases which was most commonly of microcytic hypochromic type. Eosinophilia was seen in 46/223 (20.60%) cases.
Conclusions:
Many cleft lip and cleft palate patients show high eosinophil counts. Absolute eosinophil count was found to be a better parameter for assessment of eosinophils.
