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Probing the metal specificity mechanism of superoxide dismutase from human pathogen Clostridium difficile
Wei Li1, Hongfei Wang, Zheng Chen
1Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China. xstan@fudan.edu.cn.
Chemical Communications (Cambridge, England)
|November 27, 2013
Abstract:
The molecular mechanism of the metal specificity to superoxide dismutase from human pathogen C. difficile (SODcd) was investigated by X-ray crystallography, spectroscopy, SOD activity assay, electrochemistry, and DFT calculations, and the results indicate that the cognate metal characters tuned by the metal micro-environment dominate the metal specificity of the SODcd.
