Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

Pleiotropy

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Cirrhosis I: Introduction

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

Diseases of the Liver and Gallbladder

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Spinal ozone therapy].

Der Radiologe·2021

Same author

[Spondylodiscitis and epidural abscesses].

Der Radiologe·2021

Same author

[Malignant tumors of the oral cavity].

Der Radiologe·2020

Same author

[Degenerative intervertebral disc processes : Current aspects of diagnosis].

Der Radiologe·2019

Same author

[Intracranial cystic lesions].

Der Radiologe·2017

Same author

[Kyphoplasty and vertebroplasty for spinal trauma].

Der Radiologe·2016

Same journal

Der Radiologe·2024

Same journal

Der Radiologe·2024

Same journal

Der Radiologe·2024

Same journal

Der Radiologe·2024

Same journal

Der Radiologe·2022

Same journal

Der Radiologe·2022

See all related articles

Search research articles

Related Experiment Video

Updated: May 5, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

[Osler's disease].

F Ahlhelm¹, J Lieb, G Schneider

¹Institut für Radiologie, Kantonsspital Baden AG, 5404, Baden, Schweiz, FrankJohannes.Ahlhelm@ksb.ch.

|November 27, 2013

Summary

This summary is machine-generated.

Hereditary hemorrhagic telangiectasia (HHT), or Osler's disease, causes abnormal blood vessels. Diagnosis involves clinical exams, genetic testing, and advanced imaging like CT and MRI to detect arteriovenous malformations (AVMs).

More Related Videos

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Related Experiment Videos

Last Updated: May 5, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Area of Science:

Genetics
Vascular Biology
Medical Imaging

Context:

Osler's disease, also known as hereditary hemorrhagic telangiectasia (HHT), is an autosomal dominant disorder.
It is characterized by the formation of arteriovenous malformations (AVMs) in various organs.
Patients often present with epistaxis and visible telangiectasias.

Purpose:

To review the clinical manifestations, diagnostic criteria, and imaging modalities for HHT.
To emphasize the importance of understanding radiological presentations for effective patient management.
To highlight the growing role of interventional procedures in HHT treatment.

Summary:

Diagnosis of HHT relies on clinical examination, genetic testing (Curacao criteria), and advanced imaging.
Computed tomography (CT) and magnetic resonance imaging (MRI) are crucial for depicting AVMs, with specific protocols for different organ systems.
Pulmonary AVMs are visible on CT without contrast, while CNS AVMs typically require contrast agents.

Impact:

Improved diagnostic accuracy through integrated clinical and radiological assessment.
Enhanced therapeutic strategies incorporating interventional procedures for HHT patients.
Better patient outcomes due to a comprehensive understanding of HHT's multifaceted nature.