Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

3.1K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
3.1K
Development of the Lymphatic System01:15

Development of the Lymphatic System

2.9K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.9K
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

3.2K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
3.2K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.7K
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

13.6K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
13.6K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

8.0K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obesity drives depot-specific vascular remodeling in male white adipose tissue.

Nature communications·2025
Same author

Leveraging homologous recombination deficiency for sarcoma : Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma.

Pathologie (Heidelberg, Germany)·2024
Same author

Blood flow-induced angiocrine signals promote organ growth and regeneration.

BioEssays : news and reviews in molecular, cellular and developmental biology·2024
Same author

Semaphorin-3A regulates liver sinusoidal endothelial cell porosity and promotes hepatic steatosis.

Nature cardiovascular research·2024
Same author

Inhibition of proline-rich tyrosine kinase 2 restores cardioprotection by remote ischaemic preconditioning in type 2 diabetes.

British journal of pharmacology·2024
Same author

The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling.

The Journal of clinical investigation·2024
Same journal

Christopher Addison (1869-1951): Distinguished Anatomist and Politician.

Advances in anatomy, embryology, and cell biology·2026
Same journal

Surgical Contributions to Anatomical Knowledge.

Advances in anatomy, embryology, and cell biology·2026
Same journal

The Rise and Tragic Fall of Charles Averill MRCS (1796-1830), Gentleman Surgeon of Cheltenham.

Advances in anatomy, embryology, and cell biology·2026
Same journal

Richard Owen's Golgotha: Lancaster Castle and the Prisoner's Head that Rolled.

Advances in anatomy, embryology, and cell biology·2026
Same journal

Labiaplasty: Mind the Gap-How the Female Genital Cosmetic Surgery Industry Has Exposed Gaps in Modern Medical Anatomy Education.

Advances in anatomy, embryology, and cell biology·2026
Same journal

Trends Versus Transformative Tools Within Anatomy Education: The Case for Ultrasound.

Advances in anatomy, embryology, and cell biology·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements
05:49

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

Published on: December 2, 2022

2.5K

Mechanosensing in developing lymphatic vessels.

Lara Planas-Paz1, Eckhard Lammert

  • 1Institute of Metabolic Physiology, Heinrich-Heine University, Universitätsstrasse 1, 40225, Düsseldorf, Germany.

Advances in Anatomy, Embryology, and Cell Biology
|November 27, 2013
PubMed
Summary
This summary is machine-generated.

The lymphatic system maintains fluid balance and immune cell transport. Mechanical forces, like interstitial fluid pressure, regulate lymphatic vessel expansion through mechanotransduction.

More Related Videos

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

13.8K
Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
09:52

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

Published on: March 8, 2013

15.9K

Related Experiment Videos

Last Updated: May 5, 2026

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements
05:49

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

Published on: December 2, 2022

2.5K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

13.8K
Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
09:52

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

Published on: March 8, 2013

15.9K

Area of Science:

  • Physiology
  • Developmental Biology
  • Biotechnology

Background:

  • The lymphatic vasculature is crucial for fluid homeostasis, immune cell transport, and lipid absorption.
  • Lymphatic endothelial cells (LECs) form a network of vessels with specialized junctions and anchoring filaments for fluid drainage.
  • Mechanotransduction allows LECs to sense and respond to mechanical cues such as ECM stiffness, fluid pressure, and shear stress.

Purpose of the Study:

  • To explore the role of mechanical forces in lymphatic vessel expansion during embryonic development.
  • To investigate the potential application of these mechanotransduction principles to secondary lymphedema.

Main Methods:

  • Utilizing in vitro mechanotransduction assays.
  • Employing in vivo studies, particularly in mouse embryos.
  • Focusing on the mechanosensory complex involving β1 integrin and VEGFR3.

Main Results:

  • Interstitial fluid accumulation directly influences lymphatic vessel expansion.
  • A mechanosensory complex comprising β1 integrin and VEGFR3 mediates the response to interstitial fluid levels.
  • Demonstrated the link between mechanical forces and lymphatic vessel growth in embryonic development.

Conclusions:

  • Mechanical forces, particularly interstitial fluid pressure, are key regulators of lymphatic vessel expansion.
  • The identified mechanosensory complex provides a molecular basis for understanding lymphatic development and potentially lymphedema.
  • This mechanotransduction model offers insights into lymphatic vessel dynamics in both development and disease states.