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Updated: May 5, 2026

Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain
Published on: December 12, 2017
Amino acid chemoreception: Effects of ph on receptors and stimuli
1Boston University Marine Program Marine Biological Laboratory Woods Hole, 02543, Massachusetts.
Abstract:
A current model of amino acid chemoreception has generated the idea that pH affects the efficiency of stimulus-receptor binding by altering the charge distribution on stimulus molecules. The model suggests that amino acids are maximally stimulatory near their isoelectric points. We point out that, within a broad range of pH values, changes in stimulant amino acids cannot account for altered chemoresponsiveness. We suggest instead that pH-induced changes in chemoreception are a result of changes in charge distribution on the protein receptor.
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