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Activities of Glutathione S-Transferase and Glutathione Peroxidases Related to Diet Quality in an Aphid Predator, the Seven-spot Ladybird, Coccinella septempunctata L. (Coleoptera: Coccinellidae(.

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Effect of dietary nickel and iron on the trace element content of rat liver.

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Effect of form of iron on nickel deprivation in the rat: Plasma and liver lipids.

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Interactions among nickel, copper, and iron in rats : Growth, blood parameters, and organ wt/body wt ratios.

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Effect of form of iron on nickel deprivation in the rat : Liver content of copper, iron, manganese, and zinc.

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Interactions among nickel, copper, and iron in rats : Liver and plasma content of lipids and trace elements.

Biological trace element research·2013

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Interaction between nickel and iron in the rat.

F H Nielsen1, T R Shuler, T J Zimmerman

  • 1United States Department of Agriculture, Science and Education Administration, Human Nutrition Laboratory, University of North Dakota, 58201, Grand Forks, North Dakota.

Biological Trace Element Research
|November 27, 2013
PubMed
Summary

Nickel and iron interact in rat metabolism, affecting growth and blood parameters. High nickel partially improved iron deficiency but harmed growth, suggesting complex interactions.

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Area of Science:

  • Nutritional biochemistry
  • Mineral metabolism

Background:

  • Interactions between essential minerals are crucial for understanding metabolic processes.
  • Nickel and iron are vital minerals with potential synergistic or antagonistic effects.

Purpose of the Study:

  • To investigate the metabolic interaction between dietary nickel and iron in rats.
  • To determine the effects of varying iron and nickel levels on physiological and biochemical parameters.

Main Methods:

  • A 3x4 factorial design experiment using female weanling rats.
  • Dietary supplementation with four levels of iron (0-100 μg/g) and three levels of nickel (0-50 μg/g).
  • Analysis of growth, hematocrit, hemoglobin, plasma, and liver composition after nine weeks.

Main Results:

  • Dietary iron significantly impacted growth, hematocrit, hemoglobin, plasma cholesterol, and liver composition (lipids, copper, iron, manganese, zinc).
  • Dietary nickel influenced growth, hematocrit, hemoglobin, plasma alkaline phosphatase, plasma lipids, and liver composition (lipids, copper, manganese, nickel).
  • Nickel-iron interactions were observed in hematocrit, hemoglobin, plasma alkaline phosphatase, plasma phospholipids, and liver copper and manganese content.

Conclusions:

  • Nickel and iron interact at multiple metabolic sites in rats.
  • High dietary nickel can partially mitigate severe iron deficiency symptoms but may negatively affect growth.
  • Nickel's effects can be modulated by iron status, highlighting a complex nutritional interplay.