Prostaglandin E1-induced Catalepsy in the Rat: Role of Putative Neutrotransmitters
S K Bhattacharya1, P J Rao, D Bhattacharya
1Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India.
Pharmaceutical Research
|November 27, 2013
Abstract:
Prostaglandin E1 (PGE1) produced dose-related catalepsy in rats when administered intracerebroventricularly. PGE1 induced catalepsy was significantly inhibited after pretreatment with pharmacological agents known to attenuate central serotonergic and cholinergic activity. It was also inhibited by PGF2α and naloxone. On the contrary, treatments enhancing central dopaminergic activity also reduced the cataleptic effect of PGE1. The results suggest that PGE1 induces catalepsy in rats by modulating activity of central neurotransmitters.
