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Prevalence of rotavirus diarrhea among hospitalized under-five children

M A Mathew1, Abraham Paulose, S Chitralekha

  • 1Department of Pediatrics, Malankara Orthodox Syrian Church Medical College Hospital, Kolenchery, Ernakulam District, Kerala; Department of Microbiology, Christian Medical College, Vellore, India and Division of Translational Research, International Vaccine Institute, Seoul, South Korea. Correspondence to: Dr MA Mathew, Professor, Department of Pediatrics, Malankara Orthodox Syrian Church Medical College Hospital, Kolenchery, Ernakulam District, Kerala 682 311, India. drmathew_11@yahoo.com.

Indian Pediatrics
|November 27, 2013
PubMed

Insights

Rotavirus diarrhea is prevalent in hospitalized children under 5 in Kerala, affecting 35.9% of cases. The most common strain identified was G1P[8], highlighting the need for targeted interventions.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Rotavirus is a leading cause of severe diarrheal disease in young children globally.
  • Understanding local prevalence and circulating strains is crucial for effective public health strategies.

Purpose of the Study:

  • To determine the prevalence of rotavirus diarrhea in hospitalized children under 5 years in Kerala.
  • To identify the specific rotavirus strains circulating in the region.

Main Methods:

  • A multicenter, cross-sectional study was conducted in eight hospitals in Ernakulam district, Kerala.
  • Stool samples from 1827 hospitalized children with acute diarrhea were tested using ELISA and RT-PCR for rotavirus detection and strain typing.

Main Results:

  • Rotavirus was detected in 35.9% of the children studied.
  • Prevalence varied by age, peaking in the 24-35 month group (46.9%).
  • The most common genotype was G1P[8] (49.7%), followed by G9P[8] (26.4%).

Conclusions:

  • Rotavirus diarrhea poses a significant public health burden among hospitalized children in Ernakulam, Kerala.
  • The predominance of G1P[8] strain suggests potential targets for vaccination and surveillance efforts.
Abstract

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