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Generalized lichen amyloidosis and hyperthyroidism: coincidence or association
Müzeyyen Gönül1, Seray Külcü Cakmak, Serra Kayaçatin
1Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey. Head: Prof. Dr. Nurettin Karaoğlanoğlu.
Postepy Dermatologii I Alergologii
|November 27, 2013
Summary
This study reports a rare case of generalized lichen amyloidosis (LA) in a patient with co-existing hyperthyroidism. The findings suggest a potential link between these two conditions, warranting further investigation into shared etiologic factors.
Area of Science:
- Dermatology
- Endocrinology
Background:
- Lichen amyloidosis (LA) is a skin condition characterized by pruritic papules.
- Associations between LA and various systemic diseases have been documented.
Observation:
- A 76-year-old man presented with a 2-year history of severe pruritic eruption, diagnosed as generalized lichen amyloidosis.
- Histopathology confirmed LA with eosinophilic amorphous material in the papillary dermis.
- Laboratory tests revealed decreased thyroid-stimulating hormone and increased thyroxine levels, consistent with hyperthyroidism.
Findings:
- This is the first reported case of generalized lichen amyloidosis associated with hyperthyroidism.
- The patient's thyroid gland was enlarged and heterogeneous on ultrasonography, with normal thyroid autoantibodies.
Implications:
- The co-occurrence of LA and hyperthyroidism may suggest a shared underlying etiologic factor.
- Hyperthyroidism-induced pruritus could potentially trigger or exacerbate lichen amyloidosis.
- Further research is needed to elucidate the relationship between these two conditions.
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