Related Experiment Video
Updated: May 5, 2026
Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
In vivo quantitative susceptibility mapping (QSM) in Alzheimer's disease
Julio Acosta-Cabronero1, Guy B Williams, Arturo Cardenas-Blanco
1German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany ; Neurology Unit, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
Background:
This study explores the magnetostatic properties of the Alzheimer's disease brain using a recently proposed, magnetic resonance imaging, postprocessed contrast mechanism. Quantitative susceptibility mapping (QSM) has the potential to monitor in vivo iron levels by reconstructing magnetic susceptibility sources from field perturbations. However, with phase data acquired at a single head orientation, the technique relies on several theoretical approximations and requires fast-evolving regularisation strategies.
Methods:
In this context, the present study describes a complete methodological framework for magnetic susceptibility measurements with a review of its theoretical foundations.
Findings And Significance:
The regional and whole-brain cross-sectional comparisons between Alzheimer's disease subjects and matched controls indicate that there may be significant magnetic susceptibility differences for deep brain nuclei--particularly the putamen--as well as for posterior grey and white matter regions. The methodology and findings described suggest that the QSM method is ready for larger-scale clinical studies.
