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Celiprolol in angina pectoris: a controlled study.

J Eff, J Godfrey, R Garutti

    Journal of Cardiovascular Pharmacology
    |January 1, 1986
    PubMed
    Summary
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    Celiprolol effectively improved exercise tolerance and reduced myocardial ischemia in patients with stable angina pectoris. The drug demonstrated significant increases in time to ischemia and anginal symptoms, with dose-dependent effects.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Stable angina pectoris is a common condition characterized by myocardial ischemia.
    • Exercise-induced angina requires effective anti-anginal and anti-ischemic therapies.

    Purpose of the Study:

    • To evaluate the anti-anginal and anti-ischemic effects of celiprolol.
    • To assess celiprolol's efficacy in patients with stable, exercise-induced angina pectoris.

    Main Methods:

    • Double-blind, placebo-controlled, parallel, multicenter study design.
    • Inclusion of a placebo run-in and run-out period.
    • Assessment of exercise treadmill testing (modified Bruce protocol) and double product.

    Main Results:

    • Celiprolol significantly increased time to myocardial ischemia and anginal symptoms compared to placebo.

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  • Dose-dependent improvements were observed, with the 400 mg dose showing the greatest effect.
  • Celiprolol decreased maximum exercise double product, indicating reduced cardiac workload.

    • Conclusions:

    • Celiprolol demonstrates significant anti-anginal and anti-ischemic properties.
    • The drug is effective in improving exercise capacity in patients with stable angina.
    • Celiprolol offers a potential therapeutic option for managing exercise-induced angina pectoris.