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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Chronic heart failure: we are fighting the battle, but are we winning the war?
1Cardiology Department, Royal Brisbane and Women's Hospital, Butterfield Street, Herston, QLD 4006, Australia ; School of Medicine, University of Queensland, Brisbane, QLD 4006, Australia.
Insights
Heart failure management has advanced, but prevalence is rising. Future strategies must combine improved treatments with proactive public health measures and early screening for high-risk individuals.
Area of Science:
- Cardiology
- Public Health
Background:
- Heart failure is a serious condition with poor prognosis, despite advances in neurohormonal blockade and device therapies like implantable cardioverter defibrillators and cardiac resynchronization therapy.
- Prevalence of heart failure is increasing due to an aging population and improved survival rates for cardiovascular disease patients.
Purpose of the Study:
- To highlight treatment gaps and variations in evidence-based practice for heart failure.
- To emphasize the need for a comprehensive strategy addressing both treatment and prevention to combat the rising prevalence of heart failure.
Main Methods:
- Analysis of registry data to identify treatment gaps and variations in evidence-based practice.
- Review of quality improvement initiatives and multidisciplinary heart failure disease management programs.
- Discussion of the necessity for public health measures and screening strategies for future prevention.
Main Results:
- Registries reveal significant gaps in the application of evidence-based heart failure treatments, including echocardiography and disease-modifying drugs.
- Quality initiatives and multidisciplinary management improve self-care and reduce practice variation, leading to better outcomes.
- Current approaches are insufficient to curb the rising prevalence of heart failure.
Conclusions:
- While advanced treatments have improved survival, they have not halted the increasing incidence of heart failure.
- Effective control of heart failure requires a dual approach: optimizing current evidence-based treatments and implementing robust disease prevention strategies.
- Future efforts must integrate population-level public health interventions and targeted screening to identify and manage individuals at high risk of developing heart failure.
Abstract:
Heart failure represents an end-stage phenotype of a number of cardiovascular diseases and is generally associated with a poor prognosis. A number of organized battles fought over the last two to three decades have resulted in considerable advances in treatment including the use of drugs that interfere with neurohormonal activation and device-based therapies such as implantable cardioverter defibrillators and cardiac resynchronization therapy. Despite this, the prevalence of heart failure continues to rise related to both the aging population and better survival in patients with cardiovascular disease. Registries have identified treatment gaps and variation in the application of evidenced-based practice, including the use of echocardiography and prescribing of disease-modifying drugs. Quality initiatives often coupled with multidisciplinary, heart failure disease management promote self-care and minimize variation in the application of evidenced-based practice leading to better long-term clinical outcomes. However, to address the rising prevalence of heart failure and win the war, we must also turn our attention to disease prevention. A combined approach is required that includes public health measures applied at a population level and screening strategies to identify individuals at high risk of developing heart failure in the future.
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