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Adrenaline responsiveness in borderline hypertension.

P Hjemdahl, K Lindvall, T Kahan

Journal of Cardiovascular Pharmacology

|January 1, 1986

Summary

Borderline hypertension (BHT) patients show increased arousal at rest. Adrenaline infusion revealed similar cardiovascular and beta 2-adrenoceptor responses in BHT and control groups, suggesting unaltered sensitivity.

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Area of Science:

Cardiovascular Physiology
Endocrinology

Background:

Borderline hypertension (BHT) is a condition with potential implications for cardiovascular health.
Understanding the role of circulating catecholamines like adrenaline in BHT is crucial.

Purpose of the Study:

To investigate the cardiovascular effects of adrenaline infusion in individuals with borderline hypertension.
To assess beta 2-adrenoceptor sensitivity in borderline hypertensive subjects.

Main Methods:

Infusion of adrenaline at increasing doses (0.1–0.8 nM/kg/min) in 14 BHT subjects and 14 controls.
Noninvasive cardiovascular measurements (echocardiography, blood pressure) and blood sampling for plasma catecholamines, cyclic AMP, and potassium.
Comparison of physiological responses between BHT and normotensive groups.

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Main Results:

Systolic and diastolic blood pressure responses to adrenaline were similar in both groups.
Elevated resting cardiac output in BHT was normalized during adrenaline infusion; myocardial contractility signs diminished.
Heart rate and systemic vascular resistance were higher in BHT but showed similar adrenaline responsiveness.
Beta 2-adrenoceptor-mediated increases in cyclic AMP and decreases in potassium were comparable between groups.

Conclusions:

Individuals with borderline hypertension exhibit increased physiological arousal at rest.
Beta 2-adrenoceptor sensitivity appears to be unaltered in borderline hypertension.
Adrenaline's cardiovascular effects do not differ significantly in responsiveness between BHT and normotensive individuals.