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Updated: May 5, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
Quantitative cardiac positron emission tomography: the time is coming!
1Department of Clinical Physiopathology, Nuclear Medicine Unit, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.
Quantitative cardiac positron emission tomography (PET) offers significant diagnostic and prognostic value for heart disease. Routine use of quantitative cardiac PET can improve the detection and management of coronary artery disease and microvascular dysfunction.
Area of Science:
- Cardiology
- Nuclear Medicine
- Medical Imaging
Background:
- Positron emission tomography (PET) use has surged in oncology, with facilities now widely accessible.
- PET demonstrates significant diagnostic and prognostic capabilities in cardiovascular disease through quantitative analysis.
Purpose of the Study:
- To highlight the advancements and clinical utility of quantitative cardiac PET.
- To emphasize the role of myocardial blood flow (MBF) and coronary flow reserve (CFR) measurements.
- To discuss the assessment of microvascular dysfunction in various cardiac conditions.
Main Methods:
- Development and implementation of user-friendly software for MBF quantification.
- Utilizing rest and stress MBF measurements.
- Calculating CFR from PET-derived MBF data.
Main Results:
- Quantitative PET improves the detection and prognostication of coronary artery disease.
- PET enables assessment of microvascular dysfunction in conditions like atherosclerosis and cardiomyopathies.
- MBF and CFR measurements provide crucial prognostic information.
Conclusions:
- Quantitative cardiac PET is a powerful tool for diagnosing and predicting outcomes in heart disease.
- Its ability to assess microvascular function is critical for various cardiac pathologies.
- Routine integration of quantitative cardiac PET into clinical practice is recommended for modern cardiology.
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