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Surgical Treatment of an Endolymphatic Sac Tumor
Published on: May 26, 2023
Surgery for primary filum terminale ependymomas: outcome and prognostic factors
Tian-Hao Xie1, Xian-Zhen Chen, Jun Qian
1Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Introduction:
Primary filum terminale ependymoma (PFTE) is a unique type of ependymomas and locates on extramedullary site. However, the clinical features and prognostic factors of PFTE are still unknown due to its rarity.
Aim:
This study aimed to evaluate the clinical features, outcomes, and prognostic factors of PFTE in the largest series of cases.
Result:
Thirty-eight patients were included in this study. Gross total removal (GTR) of the tumors was achieved in 33(87%) patients. Five (13%) patients had subtotal resection (STR). For the residual tumors, postoperative radiotherapy increased the interval between the first surgery and tumor regrowth (P = 0.063). Six patients had local recurrence/progression. Univariate analysis identified STR(P = 0.001), unencapsulated tumor (P = 0.018), tumor involving more than two vertebral columns (P = 0.005), and tumor invading sacral canal(P < 0.001) as predictors of tumor recurrence. In addition, 36 (95%) patients had stable or improved neurological status directly after surgery. Klekamp-Samii score was better correlated with the symptoms than McCormick scale.
Conclusion:
Extent of surgical removal, tumor size, tumor location, and the integrity of tumor capsule are the prognostic factors of PFTEs, and the intrasacral PFTEs always have a poor prognosis.
