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Published on: May 27, 2022
Infertility treatment for azoospermic patients with a history of infectious parotitis (mumps) using combined
Shuiwen Zhang1, Jianhua Li, Guoping Zhou
1Reproductive Medical Center, Beijing Military General Hospital , Beijing 100700.
Purpose:
The purpose of this study was to investigate the clinical efficacy of in vitro maturation-intracytoplasmic sperm injection (IVM-ICSI) technique on the treatment of azoospermic patients with a history of infectious parotitis (mumps).
Methods:
Spermatozoa were obtained from the testes of azoospermic patients with a history of mumps and fertilized by ICSI. Eggs were retrieved from the spouse of patients in the natural cycle. Fertilized embryos were transferred into the uterus of patients' respective spouses.
Results:
Live sperm were retrieved from 16 of out of 24 (67%) azoospermic patients with a history of mumps. Using IVM-ICSI, the normal fertilization rate was 71.2%. A total of 23 treatment cycles were completed in the spouses of 16 patients and of these, 9 patients' spouses became pregnant (a pregnancy rate of 39.1%). The success rate for infertility treatment of mumps patients was equally high at 56.3% (9/16).
Conclusion:
The IVM-ICSI technique is a simple, effective and economic method for infertility treatment in azoospermic patients with a history of mumps.
Insights
The in vitro maturation-intracytoplasmic sperm injection (IVM-ICSI) technique offers a successful treatment for infertility in azoospermic men with a history of mumps. This method achieved a high pregnancy rate, demonstrating its clinical efficacy.
Area of Science:
- Reproductive Medicine
- Andrology
- Infertility Treatment
Background:
- Mumps (infectious parotitis) can lead to azoospermia, causing male infertility.
- Azoospermia requires advanced reproductive technologies for successful conception.
- Previous treatments for mumps-induced azoospermia have had limited success.
Purpose of the Study:
- To evaluate the clinical effectiveness of the in vitro maturation-intracytoplasmic sperm injection (IVM-ICSI) technique.
- To assess IVM-ICSI as a treatment for azoospermic patients with a history of mumps.
Main Methods:
- Spermatozoa were surgically retrieved from the testes of azoospermic patients with a history of mumps.
- Retrieved spermatozoa were used for intracytoplasmic sperm injection (ICSI) with oocytes from the patients' spouses.
- Mature embryos were transferred to the respective spouses' uteruses to achieve pregnancy.
Main Results:
- Live sperm were successfully retrieved from 67% (16/24) of azoospermic patients with a history of mumps.
- The in vitro maturation-intracytoplasmic sperm injection (IVM-ICSI) technique resulted in a 71.2% normal fertilization rate.
- A 39.1% pregnancy rate was achieved, with 9 successful pregnancies out of 16 treatment cycles, leading to an overall infertility treatment success rate of 56.3% for mumps patients.
Conclusions:
- The IVM-ICSI technique is a viable and effective method for treating infertility in azoospermic patients with a history of mumps.
- This technique offers a simple, effective, and economical solution for male infertility caused by mumps.
- IVM-ICSI significantly improves the chances of conception for individuals affected by mumps-induced azoospermia.
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