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Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
Published on: March 20, 2017
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Bariatric surgery modulates circulating and cardiac metabolites
Hutan Ashrafian1, Jia V Li, Konstantina Spagou
1Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , SW11 2PH London, U.K.
Journal of Proteome Research
|November 28, 2013
Summary
Roux-en-Y gastric bypass (RYGB) surgery significantly alters cardiac and plasma metabolism in rats, enhancing energy pathways and offering cardioprotection. These metabolic shifts may explain reduced cardiovascular risk after bariatric surgery.
Area of Science:
- Metabolomics
- Cardiovascular Research
- Bariatric Surgery
Background:
- Bariatric surgery, like Roux-en-Y gastric bypass (RYGB), induces significant weight loss and cardiovascular benefits.
- The underlying mechanisms for RYGB's cardioprotective effects, particularly cardiac metabolism modifications, require further elucidation.
Purpose of the Study:
- To compare plasma and cardiac tissue metabolic profiles in RYGB-operated rats versus sham-operated controls.
- To identify the systemic and cardiac metabolic signatures associated with RYGB surgery.
Main Methods:
- Utilized (1)H nuclear magnetic resonance (NMR) spectroscopy and ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) for metabolic profiling.
- Analyzed plasma and heart tissue samples from 27 male Wistar rats 8 weeks post-RYGB or sham operation.
- Employed correlation networks to identify metabolite associations.
Main Results:
- RYGB altered plasma metabolites including bile acids, phosphocholines, amino acids, and energy-related compounds.
- Cardiac tissue in RYGB rats showed changes in glycogen and amino acid levels.
- Metabolic phenotype indicated systemic and myocardial metabolic shifts, suggesting enhanced cardiac energy metabolism and protective activities.
Conclusions:
- Bariatric surgery induces significant metabolic changes in both the heart and systemically.
- Altered metabolic profiles suggest enhanced cardiac energy metabolism via TCA cycle intermediates and cardiorenal protection.
- Surgically induced metabolic shifts, potentially involving gut microbiota and an enterocardiac axis, contribute to cardioprotection against metabolic syndrome-related cardiac dysfunction.
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