Low high-density lipoprotein cholesterol is characterized by elevated oxidative stress

Area of Science:

• Cardiology
• Biochemistry
• Oxidative Stress Research

Background:

• High-density lipoprotein cholesterol (HDL-C) plays a crucial role in preventing atherosclerosis and cardiovascular disease.
• Plasma HDL possesses significant antioxidant properties.
• Low HDL-C levels are recognized as an independent risk factor for premature cardiovascular events.

Purpose of the Study:

• To investigate the association between low high-density lipoprotein cholesterol (HDL-C) and parameters of oxidative stress.
• To evaluate oxidative stress markers in individuals with clinically defined low HDL-C levels compared to controls.

Main Methods:

• A case-control study involving 32 patients with low HDL-C (≤35 mg/dL) and 33 age- and sex-matched controls with normal HDL-C (>35 mg/dL).
• Assessment of clinical and laboratory parameters related to oxidative stress, including the oxidative stress index (OSI) and uric acid levels.

Main Results:

• Patients with low HDL-C exhibited significantly higher oxidative stress index (OSI) levels compared to the control group (3.32 AU vs 0.74 AU, P<.01).
• OSI levels demonstrated a negative correlation with HDL-C levels.
• Elevated uric acid levels were also observed in the low HDL-C group.

Conclusions:

• Low HDL-C levels are associated with a significantly increased oxidative stress status.
• The observed increase in OSI and uric acid in patients with low HDL-C may contribute to heightened cardiovascular risk.
• Targeting oxidative stress could be a potential therapeutic strategy for individuals with low HDL-C.